The ‘complexities’ of life and death: Death receptor signalling platforms

Dual Philosophy in Death Receptor Signalling

Tumour necrosis factor (TNF) is the founding member of a cytokine family with important roles in both, physiology and pathological conditions. The two seemingly opposing cellular responses to stimulation by TNF itself are death and induction of pro-inflammatory signalling. TNF and other TNF superfamily (SF) members signal by crosslinking their cognate receptors. These form part of the TNF recep...

nature of death, death-awareness and meaning of life

death has been and is the most important problem of human being throughout the history. every man is innately in the pursuit of immortality, life and well-fare as they also hate destruction and annihilation. this problem as well as related views and analyses of the true nature of death, the elements of reducing the dread of death have all direct effect on meaningfulness of life. whether or not ...

The death of costly signalling?

Death receptor signalling in central nervous system inflammation and demyelination.

Death receptors (DRs) are members of the tumor necrosis factor receptor (TNF-R) superfamily that are characterised by the presence of a conserved intracellular death domain and are able to trigger a signalling pathway leading to apoptosis. Strong evidence suggests that DRs contribute to the pathology of tissue destructive diseases, including multiple sclerosis (MS), the most common inflammatory...

Association of Death Anxiety and Quality of Life in the Caregivers of Patients with Multiple Sclerosis

Background & Aims: The progressive and debilitative nature of multiple sclerosis (MS) affects various aspects of the life of the patient and their caregivers. Care provision to MS patients may give rise to death anxiety and decrease the quality of life of the caregivers. The present study aimed to assess the correlation between death anxiety and quality of life in the caregivers of patients wit...